What is ROC?
The Resuscitation Outcomes Consortium (ROC) was created to conduct clinical research in the areas of cardiopulmonary resuscitation and traumatic injury. ROC consists of 10 Regional Clinical Centers (RCCs) and a Data and Coordinating Center (DCC) that will provide the necessary infrastructure to conduct multiple collaborative trials to aid rapid translation of promising scientific and clinical advances to improve resuscitation outcomes. Trials may evaluate existing or new therapies (such as pharmacologic immune modulators) as well as clinical management strategies (such as new resuscitative fluids, novel hemorrhage control strategies, the use of cerebral protection and neurologic preservation, metabolically directed therapies, and alternative methods of delivering CPR or defibrillation).
Who are the Sponsors?
National Heart, Lung and Blood Institute
National Institute of Neurological Disorders and Stroke
Institute of Circulatory and Respiratory Health of the Canadian Institutes of Health Research
Defence Research and Development Canada
Heart and Stroke Foundation of Canada
The ongoing direct study commitment of the sponsors is for at least 5 year funding of approximately $10 million per year.
Who will conduct the research?
The ROC consists of EMS systems and hospitals in the cities or regions listed below.
• Alabama Resuscitation Center, involving systems in Central and possibly Northern Alabama: Tom Terndrup, MD, Principal Investigator
• Dallas, TX (includes some surrounding cities): Ahamed Idris, MD, Principal Investigator
• Iowa City, IA (includes 10 cities throughout Iowa): Richard Kerber, MD, Principal Investigator
• Milwaukee, WI: Tom Aufderheide, MD, Principal Investigator
• Pittsburgh, PA (includes some suburbs): Clif Callaway, MD, Principal Investigator
• Portland, OR ( includes 4 counties): Jerris Hedges, MD, Principal Investigator
• Ottawa, Ontario /Vancouver, BC (includes 20 other cities in the OPALS group): Ian Stiell, MD, Principal Investigator, Jim Christenson, MD, Co-Principal Investigator in Vancouver BC
• San Diego, CA (includes the entire county): Dave Hoyt, MD, Principal Investigator
• Seattle/King County, WA: Peter Kudenchuk, MD, Principal Investigator
• Toronto, Ontario (includes surrounding areas): Art Slutsky, MD, Principal Investigator, Laurie Morrison, MD and Paul Dorian, MD, Co-Principal Investigators.
The Study Chair is Myron L. Weisfeldt, MD, Chair of Medicine at Johns Hopkins; the co-chair for cardiac arrest is Joseph Ornato, MD, Head of the Emergency Medicine Department at the Medical College of Virginia.
The Clinical and Data Coordinating Center is located at the University of Washington, Seattle, WA under the direction of Al Hallstrom, PhD and Graham Nichol, MD.
The Ethics Officer is Jeremy Sugarman, MD, MPH, MA, Berman Bioethics Institute, Johns Hopkins University.
What kind of research will potentially be conducted?
Relevant clinical trials conducted by ROC may include, but are not limited to, the following scientific needs and considerations:
• Evaluation of pharmacologic interventions to address a three-phase (electrical, circulatory, and metabolic) approach to resuscitation from cardiac arrest.
• Evaluation of optimal strategies of fluid resuscitation including permissive hypotension, timing of initiation of infusion, and use of alternative fluids particularly after traumatic injury.
• Use of immune modulators in improving clinical outcomes by altering systemic and/or regional inflammatory responses accompanying shock or shock-like states.
• Evaluation of novel hemorrhage control strategies.
• Use of cerebral protection and neurologic preservation, with an emphasis on functional outcome.
• Evaluation of metabolically directed therapies, such as a rapid induction of moderate systemic hypothermia and other novel methods to reduce metabolic demands in the immediate post-arrest/resuscitation interval.
• Evaluation of alternative CPR approaches including device-assisted CPR including defibrillators.
• Evaluation of optimal ventilation and oxygen delivery systems and methods for airway protection.
ROC Q's And A's
Information for Research Ethics Boards
Toronto Regional RESCuNet